Desmond was born to a Yoruba father and an Igbo mother, and grew up in the Northern part of Nigeria. He is also married to an Akwa-Ibom woman. He went to Air Force Primary school in Jos and later attended St John's College also in Jos. In 2003 he graduated from Lagos State University (LASU) where he studied Economics.
He started his acting career by playing roles in soap operas like Everyday People, One Too Much and Saints and Sinners. He is now one of Nollywood's leading actors having appeared in over two hundred films including Men Who Cheat, Yahoo Millionaire and Atlanta. In the year 2009, he was nominated for the Best Actor category at the Nigeria Entertainment Awards, in 2010, he was competing to become the ambassador for the Face of Hope Project, a "volunteer-based non-profit, non-religious, non-political organization established to give hope to the hopeless", in which he will work toward fixing "child illiteracy in Nigeria and Africa at large" if he is the victor.